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Genetic polymorphisms in the NPPA gene is not only related to the occurrence of hypertension, but also to the efficacy of hypertensive drug treatment. Studies have shown that patients with polymorphic C alleles of the NPPA 2238 genetic locus have increased sensitivity to diuretic drugs.NPPA (2238T>C)CYP3A5*3 Detection Kit (PCR-Melting Curve Method)
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Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are key enzymes in the methionine-folate metabolism system, involving in the regulation of folic acid metabolism and in maintaining normal homocysteine levels in the body. People carrying mutated MTHFR/MTRR genotypes may have disordered folic acid metabolism, which leads to increased risks of neonatal neural tube defects, Down syndrome, and cleft lip and palate.…Human MTHFRMTRR Gene Polymorphism Detection Kit
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The MTHFR gene encodes methylene tetrahydrofolate dehydrogenase, a rate-limiting enzyme that regulates the metabolism of folate and methionine. It plays an important role in folate metabolism, DNA methylation, and DNA synthesis. The most common polymorphism of the MTHFR gene is C677T, which locates in the catalytic domain of MTHFR, and its polymorphism leads to decreased enzyme activity and thermolability.Human MTHFR (C677T) Gene Polymorphism Detection Kit
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Ankylosing spondylitis (AS) is a rheumatic disease characterized by the involvement of the central axis, peripheral joints, chronic inflammation, and the formation of new bones.Human Leukocyte Antigen B27 PCR Detection Kit
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The human leukocyte antigens (HLA) allele B*5801 is highly related to an allergy to allopurinol, a commonly used drug for the treatment of gout and hyperuric acid. Individuals carrying the HLA-B*5801 gene have much higher risks of blindness, death, and Stevenson-Jonson syndrome after allopurinol treatment.Human HLA-B*5801 Gene PCR Detection Kit
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The human leukocyte antigens (HLA) allele B*1502 is strongly correlation with severe skin adverse reactions caused by carbamazepine. People carrying HLA-B*1502 have a much higher risk of severe drug eruption and exfoliative dermatitis (SJS/TEN) after taking carbamazepine.Human HLA-B*1502 Gene PCR Detection Kit
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The enzyme cytochrome P450 2C19 (CYP2C19) participates in the metabolism of a wide array of therapeutic drugs. Patients with different genotypes have been documented to have varied CYP2C19 enzyme activities and drug metabolism, resulting in significant differences in efficacy and toxic side effects of drugs.Human CYP2C19 Genotyping Detection Kit (PCR-Melting Curve Method)
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Aldehyde Dehydrogenase 2 (ALDH2) is an important mitochondrial enzyme governing ethanol metabolism. It displays a very attractive prospect in the screening, diagnosis and evaluation of the prognosis of many diseases.Human ALDH2 Gene Nucleic Acid Detection Kit
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Hypertension is an independent risk factor of cardiovascular and cerebrovascular diseases. Because of the genetic variation in drug-related metabolic enzymes and receptors, people may have different responses towards drugs used in hypertension treatment, which are very common in clinical practice.CYP2D6*10CYP2C9*3 ADRB1AGTR1ACE Detection Kit